An EXE file is a Windows executable program file designed specifically for Microsoft's operating system. macOS, being a different system with distinct core architecture and executable formats (like APP bundles and UNIX executables), lacks the built-in ability to directly launch or run .exe files. This fundamental incompatibility means double-clicking an EXE won't work on a Mac.

Mac users have a few main options to run Windows EXE files. The first is using compatibility layers or virtualization software like Parallels Desktop or VMware Fusion. These tools create a complete Windows environment within macOS, allowing you to install and run Windows programs. Alternatively, solutions like CrossOver use the Wine compatibility layer to translate Windows API calls to macOS equivalents, enabling many EXEs to run directly without a full Windows installation. Remote desktop software connecting to a physical Windows PC is another practical approach used across various industries.

While these solutions enable Mac users to access critical Windows-exclusive applications, such as specialized engineering tools or legacy corporate software, they come with trade-offs. Virtualization requires significant system resources (RAM, storage), purchasing a Windows license, and managing updates. Compatibility layers like Wine aren't perfect; some complex or DRM-protected software may fail. Users must also ensure compliance with software licensing terms. As macOS-native application development continues to grow, the reliance on running Windows EXE files on Macs has decreased, but these methods remain vital for specific workflows.